MOTS-C

MOTS-c is a 16-amino-acid peptide encoded in mitochondrial DNA, not nuclear DNA. It belongs to a small group called mitochondrial-derived peptides (MDPs). Researchers study it to understand how mitochondria send signals to the rest of the cell. Project Amino supplies research-grade MOTS-c for laboratory use only.

For laboratory research use only. Not for human or veterinary use.

MOTS-c at a Glance

• Full name: Mitochondrial Open Reading Frame of the 12S rRNA type-c
• Type: mitochondrial-derived peptide, 16 amino acids
• First described: 2015
• Pathway studied: AMPK signaling
• Grade: 99%+ purity, COA per batch

What Is MOTS-c?

• Most peptides are coded by DNA in the cell nucleus. MOTS-c is coded by a short section of mitochondrial DNA (the 12S rRNA gene).
• In cell studies, it moves from the mitochondria to the nucleus under metabolic stress.
• There it is studied for its role in switching on the AMPK pathway, a key energy sensor in cells.
• In plain terms: a message the cell’s power plants send to its control center.

Research Areas

• AMPK signaling: how MOTS-c activates the AMPK energy-sensing pathway in cell models [1]
• Mitochondria-to-nucleus signaling: its movement to the nucleus and effect on gene expression under stress [2]
• Aging models: physical-function measures in aged mouse studies [3]
• Mitochondrial biology: MDPs as a class of signaling molecules

Specifications

Quality and Testing

• Purity: minimum 99%, confirmed by HPLC
• Identity: confirmed by mass spectrometry
• Testing: independent third-party lab, every batch
• Documents: certificate of analysis (COA) per batch on the product certificates page
• Made in: USA

Lab Storage

• Keep sealed lyophilized powder cold, dry and away from light.
• Refrigerate reconstituted solution at 2–8 °C.
• Record batch number, concentration and date for traceability.

Related Research Materials

• Batch certificates of analysis
• All research peptides

Frequently Asked Questions

What is MOTS-c?

MOTS-c is a 16-amino-acid peptide encoded in mitochondrial DNA. It is a mitochondrial-derived peptide studied in research on AMPK and cell signaling.

Why is MOTS-c called a mitochondrial-derived peptide?

Because it is coded by mitochondrial DNA (the 12S rRNA gene) rather than by DNA in the cell nucleus.

What pathway is MOTS-c studied for?

Mainly the AMPK pathway, a cellular energy sensor, along with mitochondria-to-nucleus signaling.

What purity is Project Amino MOTS-c?

Minimum 99% by HPLC, identity confirmed by mass spectrometry, with a third-party COA for every batch.

Is MOTS-c for human use?

No. Research-grade MOTS-c is sold for laboratory research only and is not for human or veterinary use.

Important Regulatory Notice

MOTS-c sold by Project Amino is a research chemical for laboratory and research use only. It is not a drug, supplement or medical product, and it is not approved by the FDA. It is not intended for human or veterinary use, or for the diagnosis, treatment, cure or prevention of any disease. All statements summarize published research and are for educational purposes only. Purchasers must be 21 or older and are responsible for compliant handling.