This formulation combines two synthetic heptapeptides developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, each engineered with a C-terminal Pro-Gly-Pro motif that confers resistance to rapid enzymatic degradation. Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is an analogue of the adrenocorticotropic hormone ACTH(4-7) fragment, studied as a neuroprotective and nootropic compound that upregulates the neurotrophins brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF). Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is an analogue of the immunomodulatory peptide tuftsin, studied as an anxiolytic that acts through positive allosteric modulation of the GABAergic system, with additional serotonergic and immunomodulatory activity. The two are frequently studied together because they share a structural design strategy and a central nervous system research field, yet engage pharmacologically distinct mechanisms. This blend is for laboratory research use only.
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Semax is among the most extensively studied of the Russian-developed regulatory peptides. Animal studies referenced in the literature have examined changes in brain-derived neurotrophic factor (BDNF) levels and gene expression and TrkB-related signaling in association with Semax [3]. Research has characterized it as an ACTH(4-10) analogue with nootropic-class activity [3], and additional studies have examined its binding to neural tissue, making it a tool compound in research on neuroplasticity-related pathways [4].
Semax has been used in preclinical cerebral ischemia and oxidative-stress models as a research tool. Gene expression studies have examined how Semax is associated with the expression of genes related to neural and vascular function in rat brain [4]. These studies provide a molecular basis for the neuroprotection research framing applied to the compound [3, 4].
Selank is studied as a positive allosteric modulator of the GABAergic system. Research published in PMC has examined its activity in rodent stress models in comparison with classical benzodiazepine reference compounds [1], and a separate study examined how Selank is associated with the expression of genes involved in GABAergic neurotransmission [2]. This supports allosteric modulation of the GABAergic system as a proposed molecular mechanism studied in laboratory models [1, 2].
As a tuftsin analogue, Selank has been examined for modulation of interleukin-6 expression and T helper cell cytokine balance, for effects on monoamine neurotransmitter concentrations and serotonin metabolism, and for association with hippocampal BDNF expression in rats [1, 2]. These properties make Selank a research tool spanning GABAergic, immunomodulatory, and neurochemical investigation.
The following citations are drawn from publications indexed on PubMed (pubmed.ncbi.nlm.nih.gov), PubMed Central (pmc.ncbi.nlm.nih.gov), and PubChem (pubchem.ncbi.nlm.nih.gov).
These products are for research use only and are not intended for human consumption, therapeutic use, or diagnostic purposes. All compounds described herein have not been approved by the FDA for human use. These products are strictly intended for in vitro laboratory research and analytical purposes when conducted by qualified research professionals in licensed facilities. Users are responsible for ensuring compliance with all applicable laws regarding purchase and use of these materials.
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